Jayapataka Swami: Lord Caitanya said that no matter how fallen one is, how many sinful acts they have performed, He can deliver them. The only thing is that if the person is a blasphemer of a vaisnava, je vaisnava ninda kore, Lord Caitanya said, He won’t deliver them, until he gets forgiven. So transgender, I don’t see that as a big problem. But after taking initiation or after coming to Krsna consciousness they have to follow certain rules. I know one couple, they are both transgender. The man was previously a man and the woman was previously a man. Now they are transgender and married each other and practicing Krsna consciousness. We don’t recommend it but there is still hope to get the mercy of Lord Caitanya.